The immune system is a complex network of cells that works to maintain balance in the body, pretty much like an internal sensing organ. Its responses are shaped by environmental factors such as viruses and microplastics, which can influence chronic diseases like diabetes and cancer. Recent advances in single-cell technologies provide deeper insights into immune function, aiding personalized treatments like immunotherapy. Our consortium consists of academic experts that will work together to identify immune markers for chronic diseases, using new technologies and involving patient organizations, clinicians, and even an art gallery to make a broad scientific and societal impact.